Endocrine Abstracts

One of the main consequences of vessel pruning and inhibition of neovessel growth produced by angiogenesis inhibitors is increased intra-tumor hypoxia. Nevertheless, growing evidence indicates that tumor cells escape from this hypoxic environment to better nourished locations, presenting hypoxia as a positive stimulus for invasion. Indeed, we and others have described a pro-invasive and pro-metastatic adaptation to VEGFR-targeted antiangiogenic therapy that implicates hypoxia ...